INTERNATIONAL WORKSHOPS ON GENOTOXICITY TESTING (IWGT)

OUR IMPACT

IWGT’s collaborative approach has delivered breakthrough advances that have transformed genotoxicity testing worldwide and directly influenced internationally recognised regulatory testing guidelines.

Development and revision of OECD test guidelines

• Refined concentration protocols for in vitro genotoxicity studies, improving test reliability and reproducibility
• Global Evaluation Factor (GEF) development for the Mouse Lymphoma Assay (OECD 490)
• Standardizing interpretation criteria across the OECD genotoxicity test guidelines
• Pioneering comet assay guidance (Tice et al., 1990) that preceded OECD 489 by over a decade
• OECD 470 Pig-a assay, laid the scientific groundwork for this in vivo mutagenicity assay that reduced the use of animals

Regulatory Impact

• Integrated testing strategies Generated foundational data that became the basis for modern integrated genotoxicity testing approaches such as those recommended by ICH
• Photogenotoxicology sunsetting provided evidence-based rationale for discontinuing outdated testing requirements

Through careful planning, collaborative discussion, and commitment to scientific rigor, IWGT continues to shape how the global community approaches genotoxicity testing, ensuring both scientific advancement and regulatory clarity.